The Effect of Herniarin on Spatial Working Memory, Pain Threshold, and Oxidative Stress in Ischemic Hypoperfusion Model in Rats

Background: Ischemia causes severe neuronal damage and induces oxidative stress, memory impairment, reduces pain threshold. Herniarin is a powerful antioxidant. Objectives: This study aimed to evaluate the effect of herniarin on memory, pain, stress in an ischemia model male rats. Materials & Methods: In this study, 50 rats were divided into 5 groups control, sham, ischemic, two other ischemic groups, which received at doses 150 300 mg/kg by gavage for 14 days. Behavioral tests performed shuttle box, Y-maze Tail-Flick test. Then, rats’ brains extracted lipid peroxidation measure levels thiol Glutathione Peroxidase (GPX) hippocampus striatum tissues. The results expressed as Mean±SEM then analyzed using suitable statistical methods ANOVA least significant difference post-hoc test SPSS V. 20. Results: significantly increased avoidance spatial thresholds different concentrations (P<0.001). Besides, amount malondialdehyde (MDA) group comparison control Also, group, GPX (P<0.001) decreased. Decreased MDA observed with administration (P<0.01). Conclusion: According study’s results, can remove free radicals oxidant substances from brain. Thus, it improves brain hypoperfusion model.